AD is a neurodegenerative disorder most prominently characterized by dementia and sensory system dysfunction, and it is histopathologically defined by the presence of amyloid beta (Aβ) plaques as well as intraneuronal neurofibrillary tangles (NFTs) of hyperphosphorylated Tau protein (pTau) (Cras et al., 1991; Price et al., 1991). The gene discussed is MAPT; the disease is Alzheimer disease.