With the goal of generating new human RO models of histopathology from EOFAD patients with APP mutations, we used two different hiPSC lines derived from patients with familial forms of AD: UCSD239iAPP2-1 (F, APP duplication) and HVRDi001-A-1 (M, p.Val717Ile “London” mutation in APP). This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.