TGFB1 and Cirrhosis: Our examination of 108 proteins from the TGF-β family members [4, 19] and some known biomarkers for HCC [7, 31–34], after unsupervised clustering of markers and patients using our batch-1 data, revealed a promising proteomic pattern that differentiates cirrhosis from HCC, using an early cohort of N = 170 (Figure 1A).