SPTBN1 and hepatocellular carcinoma: Moreover, liver-specific knockout of Sptbn1 (βS-LSKO) or siRNA targeting βII-spectrin reduces diet-induced MASH and protects against HCC [29], suggesting that targeting βII-spectrin may be a viable strategy to better understand mechanisms, as well as identify new biomarkers of MASH and steatosis-associated HCC and effects on restoration of metabolic function [29].