Risk factors of hypoglycemia, in addition to the use of insulin, include advancing age, duration of diabetes, kidney disease, alcohol use, malnutrition, prior history of hypoglycemia and presence of impaired awareness of hypoglycemia (IAH) (Davis et al., 2010; Seaquist et al., 2013; Karter et al., 2017; Henriksen et al., 2018). This evidence concerns the gene INS and diabetes mellitus.