IL1R1 and ulcer disease: Co-expressed gene modules within the heterogeneous tissular inflammatory response which map to specific histopathological & cellular characteristics (pathotypes)Pathotype definition ➔ high neutrophil infiltration, fibroblasts activation & vascular remodeling at regions of deep ulcerationActivated fibroblasts in the ulcer bed present IL-1R-dependent neutrophil-chemoattractant effectsPathotype-related neutrophil & fibroblast signatures ➔ increased in non-responders to various treatment options suggesting a biological rationale for the blockade of IL-1 signaling in ulcerating disease