PRKD1 and neoplasm: Specifically, LIF and GM-CSF secretion was PKD-dependent in the metastatic cell lines MDA-MB-231, MDA-MB-468 and MDA-MB-436, compared to one primary tumor cell line while the secretion of IL-11 and MMP-13 was found to be regulated by PKD only in metastatic TNBC cells (Figures 5A and 5B).