,36,37,38,39,59,60,75 In pancreatic cancer cell lines, PKD2 is known to regulate the secretion of MMP-2, MMP-7 and MMP-9 via a multiprotein complex with ARF1 and ARL1, and Arfaptin2,28,76 aiding the invasion of cells in vitro and in vivo.28 Here, ARF1 is linked to familial pancreatic carcinoma.