,2,3 Acute promyelocytic leukemia (APL) is a distinct subtype of AML characterized by the expansion and accumulation of leukemic cells that are blocked at the promyelocytic stage of granulocyte differentiation, as well as the presence of a specific disease driver fusion gene encoding the PML/RARα oncoprotein.4 This evidence concerns the gene PML and acute promyelocytic leukemia.