found that the Paeoniae radix alba polysaccharides have an inhibitory effect on the immune inflammatory response of experimental autoimmune hepatitis model mice by inhibiting of the NF-κB signal path, reducing the hepatic infiltration of inflammatory CD8+ and CD4+ T cells, and decreasing the overexpression of the inflammatory cytokines IL-10, IL-6 and IL-2. The gene discussed is CD8A; the disease is autoimmune hepatitis.