TGF-β1 is involved in the differentiation of PMFBs of resident fibroblasts and also in the mesenchymal conversion of endothelial cells via endothelial-to-mesenchymal transition (EnMT), which call forth to target vasculopathy for the abrogation of fibrosis (Zeisberg et al., 2007; Zeisberg et al., 2008; Li et al., 2009; Beyer et al., 2012). This evidence concerns the gene TGFB1 and vascular disorder.