Proteins from the complement system [161,162] and the complement-interacting protein PTX3 [163] were also enriched under + MMC conditions; considering their antimicrobial functions [[161], [162], [163]] and the tissue reparative effects of PTX3 [164], the clinical application of +MMC may be associated to lower post-operative infection rates and better healing profiles. Here, PTX3 is linked to infection.