BACE2 and Alzheimer disease: The results of this study indicated significant early-stage downregulation of AD-related genes Ubiquinol-Cytochrome C Reductase Core Protein 2 (Uqcrc2), protein coding gene Beta-Secretase 2 (Bace2), Serine Peptidase Inhibitor 3 N (Serpina3n), and Insulin-like Growth Factor-2 (Igf2) in the TA muscle tissue of TgF344-AD rats at 12 months.