Significant downregulation of AD-related genes in the TgF344-AD rat at 12 months of age was found in: Uqcrc2 (FC = 0.208; p = 0.003; d = 6.712), Bace2 (FC = 0.022; p = 0.019; d = 3.117), Serpina3n (FC = 0.017; p = 0.038; d = 2.502), and Igf2 (FC = 0.461; p = 0.054; d = 2.200). This evidence concerns the gene BACE2 and Alzheimer disease.