AD is generally known for hallmark signs such as progressive memory loss and cognitive dysfunction due to inflammation, abnormal presence of tau protein, and β-amyloid plaques that disrupt normal neuronal function and can lead to apoptotic loss of neurons in frontal and temporal cortex (Goedert, 2015; Jack et al., 2018; Breijyeh and Karaman, 2020; Trejo-Lopez et al., 2022). The gene discussed is MAPT; the disease is Alzheimer disease.