MAPT and Alzheimer disease: Specifically, some of the earliest communication changes in prodromal AD are characterized by subtle changes to temporal speech parameters in individuals who are clinically unimpaired, but show evidence of abnormal, global β-amyloid and/or tau deposition (Mueller et al., 2016, 2018a,b, 2021; Mazzon et al., 2019; Hajjar et al., 2023).