PTEN and hepatocellular carcinoma: Another study revealed that circMRPS35 exerted its oncogenic function in HCC not only by sponging miR-148a to modulate the STX3-PTEN pathway, but also by being translated into circMRPS35-168aa, resulting in cisplatin resistance, which indicated that circMRPS35 could be a crucial factor in the progression and chemoresistance of HCC with different expression patterns under different conditions (16).