PTEN and hepatocellular carcinoma: Another study revealed that circMRPS35 exerted its oncogenic function in HCC not only by sponging miR-148a to modulate the STX3-PTEN pathway, but also by being translated into circMRPS35-168aa, which resulted in cisplatin resistance, indicating that circMRPS35 might be a vital component in the progression and chemoresistance of HCC with different expression patterns under different conditions (16).