GSK3B and hepatocellular carcinoma: A recent study discovered that circβ-catenin was translatable and highly expressed in HCC, and translation of circβ-catenin generated a novel isoform named β-catenin-370aa that promoted HCC progression by protecting β-catenin from GSK3β-induced degradation and thus indirectly facilitating activation of the Wnt/β-catenin pathway (15).