For instance, circβ-catenin was translatable and highly expressed in HCC, and circβ-catenin translation generated a novel isoform named β-catenin-370aa, which subsequently promoted HCC progression by protecting β-catenin from GSK3β-induced degradation and thus facilitated the activation of the Wnt/β-catenin pathway (15). Here, GSK3B is linked to hepatocellular carcinoma.