PRPF19 and hepatocellular carcinoma: Interestingly, circRNA-SORE, a novel circRNA, played a momentous role in the maintenance and spread of sorafenib resistance in HCC by interacting with Y-box binding protein 1 (YBX1) to change its subcellular localization and sequentially preventing PRP19-mediated YBX1 ubiquitination and degradation (14).