Notably, circRNA-SORE was delivered by exosomes, which promoted transmission of sorafenib resistance among HCC cells (14).Moreover, exosomal circ-0004277 directly derived from HCC cells can be delivered to normal surrounding cells and may modulate their biological functions by suppressing the expression of ZO-1 and stimulating the development of EMT (84). This evidence concerns the gene TJP1 and hepatocellular carcinoma.