OGN has been recently related to interstitial lung disease where it has been demonstrated that the ectopic expression of miR-140 and the subsequent down-regulation of OGN in bleomycin-treated mice lung fibroblasts, resulted in increased lung fibroblast apoptosis and Wnt3a expression, together with reduced proliferation and pulmonary fibrosis (59). This evidence concerns the gene OGN and pulmonary fibrosis.