Importantly, KLF6 genes in apoptotic signaling were found to be significantly downregulated in male IDHwt GBM patients in comparison to females, while NFAT5 genes associated with cell migration were significantly downregulated in all female GBM patients compared to males, unveiling a possible mechanism for the sexual dimorphism of aggressivity of male versus female GBM tumors (34). This evidence concerns the gene NFAT5 and glioblastoma.