This dimorphism of the immune system between sexes has been shown to influence survival, with both specific gene enrichment of the adaptive immune system (TREM2, CD74, and CYTIP) and a low mMDSC/gMDSC tumor ratio and increased peripheral gMSDC expression correlating to a significantly increased OS in female murine GBM models compared to male murine GBM models (37, 38). Here, TREM2 is linked to glioblastoma.