Looking at common cancer driver mutations—such as tumor protein 53 (TP53), phosphate and tenesin homolog (PTEN), and neurofibromatosis type 1 (NF1)—also revealed sex-specific clonal statuses, with mutation of these genes having a clonal tendency in mesenchymal females but a subclonal tendency in mesenchymal males (9). This evidence concerns the gene TP53 and cancer.