TP53 and neoplasm: High expression of p53R172H in female astrocytes and p53Y202C and p53Y217C in male astrocytes was able to increase growth in comparison to p53 KO astrocytes; Inoculation of these transformed astrocytes into mice led to a higher percentage of in vivo tumor formation and higher volume tumors when compared to astrocytes of the opposite sex with the same mutation (p53R172H female 83.3% vs. male 16.7%; p53Y202C female 50% vs. male 66.6%; p53Y217C female 16.6% vs. male 100%) (26).