HMOX1 and breast carcinoma: Compounds like BAY 11-7085 can induce ferroptosis through the Nrf2-SLC7A11-HO-1 pathway, and overexpression of heme oxygenase-1 (HO-1), encoded by HMOX1, has been observed in MDA-MB-231 breast cancer and DBTRG-05MG glioblastoma cells (134).