METTL3 and colorectal carcinoma: Coincidentally, the expression of METTL3 in CRC cells activates the transcription of C-X-C motif chemokine ligand 1 (CXCL1) through upregulation of basic helix-loop-helix family member 41 (BHLHE41) in an m6A-dependent manner, and thereby enhances the migration of MDSCs to inhibit CD8+ T cells, forming an immunosuppressive TME (28).