Cocultures of PBMC and pancreatic cancer cells (AsPC-1, MIA PaCa-2, and PANC-1) in the presence or absence of B7-H3-SDIE or control mAb iso-SDIE were analyzed for the expression of the activation markers CD69 and CD25 on NK cells upon counterstaining for CD56, CD3 and CD16 after 24 h by flow cytometry. This evidence concerns the gene FCGR3A and familial pancreatic carcinoma.