Another approach which is frequently pursued are B7-H3 targeting CAR T cells, which are being evaluated in various tumor entities including advanced pancreatic carcinoma (NCT04897321, NCT05211557, NCT05341492, NCT04483778, NCT05323201, NCT05241392, NCT05474378, NCT03198052, NCT04185038, NCT05366179, NCT04670068, NCT05143151). This evidence concerns the gene CD276 and exocrine pancreatic carcinoma.