TGFB1 and cancer: In line with previous publications showing TGFb inhibition disrupts DNA repair processes in cancer cells and HSCs, these four inhibitors also disrupted several DNA repair proceses in our Ercc1 FBs (Supplementary Figure S5A) (Zhang et al., 2016; Pal et al., 2017; Liu et al., 2019; Liu et al., 2021).