Similarly, in vivo partial reprogramming studies show a more robust improvement to lifespan in progeria models indicating an ability to respond to deleterious cell states (Ocampo et al., 2016; Alle et al., 2022) Previously, it was shown improved DNA repair via overexpression of the HR protein Rad51 enhances reprogramming efficiency (Lee et al., 2016). Here, RAD51 is linked to progeroid syndrome.