Compared to the control group, naringenin significantly decreased Akt and mTOR phosphorylation and promoted AMPKα phosphorylation in NSCLC cells (Figure 4I and S7B), indicating that naringenin altered the expression of autophagy-related proteins by activating AMPKα and inactivating the Akt and mTOR signaling pathways. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.