Further animal experiments showed that JPJDR was able to lower liver metastasis of colorectal cancer (CRC) by modulating ITGBL1-rich EVs from CRC secretion, and block the ITGBL1-TNFAIP3-NF-κB signaling transmission to repress the activation of fibroblasts135 (Figure 4). This evidence concerns the gene ITGBL1 and colorectal cancer.