ACLY and colorectal cancer: Intriguingly, it has also been acknowledged that CAFs can reinforce the evolution of PMN by virtue of metabolic reprogramming, which has been substantiated by the fact that exosomes HSPC111 derived from the colorectal cancer cells tends to alter the lipid metabolism of CAFs through resulting in the phosphorylation of ATP citrate lyase (ACLY), thereby improving the expression level of acetyl CoA.