This strategy was validated in the retardation of PMN formation in melanoma, in which a low molecular weight heparin-tocopherol succinate nanoparticle was developed to block P-selectin/PSGL-1-triggered adhesion between myeloid-like MDSCs (G-MDSCs) and ECs to diminish the extravasation of G-MDSCs and suppress the level of matrix metalloprotein-9 (MMP-9) in the G-MDSCs123. Here, MMP9 is linked to melanoma.