MTOR and diffuse astrocytoma: It has been shown that IDH mutations are absent in PAs and present in association with KIAA1549-v-Raf murine sarcoma viral oncogene homolog B (BRAF) gene fusion, mitogen-activated protein kinase (MAPK), and mammalian target of rapamycin (mTOR) activation pathways [1], which result from a somatic chromosomal duplication of 7q34 [9], an indicative tool to differentiate it from diffuse astrocytoma [5].