Univariate analysis revealed that IAP (OR = 1.787, p < 0.001), diabetes status (OR = 5.314, p < 0.05), use of renin-angiotensin system inhibitor (RASi) medications (OR = 0.282, p < 0.05), and proteinuria (OR = 4.167, p < 0.05) were influencing factors for RRF decline. The gene discussed is REN; the disease is diabetes mellitus.