LRP5 and neoplasm: These included LRP5 (WNT receptor) and PEAK1 (focal adhesion kinase) within 2% of primary tumor cells in patient P25 (described above); GHSR (ghrelin growth hormone receptor) and NPRL3 (mTORC1-regulating GATOR1 subunit) within 1.5–3% (depending on possible multiplicity factors) of primary tumors cells in patient P39; and COL4A2 (a collagen involved in focal adhesion, relaxin signaling, and protein digestion and absorption pathways) and SETD1B (histone lysine methyltransferase) in 4–19% of primary tumor cells in patient P12.