CCL2 and glioblastoma: Additionally, high BACH1 expression is positively correlated with increased expression of immune checkpoints (ICs, such as CD276, TIM-3, LAG3, TIGIT and LGALS9), TAM chemokines induced by glioblastoma cells (including MCP1, mGM-CSF, and EGF) and M2 TAM markers, which means that BACH1 contributes to an immunosuppressive TME in glioblastoma [140].