BACH1 and breast cancer: However, in breast cancer, C-X-C motif chemokine receptor 3-B (CXCR3-B) induced by its ligands facilitates the activation of p38-MAPK and inhibits ERK-1/2, while also increasing the nuclear localization of BACH1 and nuclear export of Nrf2, leading to inhibition of CXCR3-B-associated signaling pathways, promoting apoptosis while inhibiting proliferation [133].