Since HPO is a DB that uses phenotype terms to tag genes and diseases, we have exploited this dual property to screen for the genes that share at least 10 out of 22 Retinitis Pigmentosa HPO-terms (RP-HPO), resulting in a total of 22 RP-HPO-terms, as shown in Table 2. The gene discussed is GFER; the disease is retinitis pigmentosa.