In the COX regression unifactor analysis, several factors were significantly associated with an increased one-year mortality rate, including older age (≥ 80 years), CCI > 2, fracture site, heart disease, brain disease, anemia, length of hospital stay, blood transfusion, ASA > 2, GNRI ≤ 579.39, SII ≥ 1621.92, low albumin levels, low body weight, and high SII–GNRI score (2–3 points). The gene discussed is ALB; the disease is anemia.