Polymorphism of immune-associated genes located in X chromosome results in more cell diversity in females than males [86, 87], with differences in TLR7/8 and type 1 interferon production, crucial in viral infections [88], cytokine modulation [84] and MicroRNAs, involved in granulocyte generation and maturation [89, 90], among other immune activities [91]. The gene discussed is TLR7; the disease is viral infectious disease.