In addition, our ex vivo results indicated that PBMCs from lung cancer patients with high expression of Rab37 positively correlated with the population of PD-1+/TIM3+CD8+ T cells accompanied with negative correlation with anti-tumor activity (GzmB+/IFN-γ+) in CD8+ T cells and diminished tumoricidal activity. This evidence concerns the gene CD8A and lung cancer.