The overall colocalization levels of Rab37, PD-1 and TIM3 were low in tumor-infiltrating CD8+ T cells in patients with better survival (Fig. 5A), whereas the colocalization levels of Rab37+/PD-1+/TIM3+/CD8+ T cells were increased in the patients with poor survival (Fig. 5B). The gene discussed is RAB37; the disease is neoplasm.