The results showed that PBMCs from lung cancer patients exhibited significant positive correlation between Rab37 expression and population of PD-1+/TIM3+/CD8+ T cells (Fig. 4H), which accordingly had negative correlation with anti-tumor activity (GzmB+/IFN-γ+) in CD8+ T cells (Fig. 4I). This evidence concerns the gene HAVCR2 and lung cancer.