AKT1 and Familial prostate cancer: Peacock et al. found that SEMA3C is a secreted soluble autocrine growth factor that promotes the growth of prostate cancer via Plexin B1- and NRP1‐mediated transactivation of EGFR, HER2/ErbB2, and MET signaling with activation of downstream signaling pathways such as SRC, MAPK, and PI3K/AKT pathways [16].