With the rapid accomplishment of high-throughput sequencing and bioinformatics analysis, an increasing number of biomarkers has been detected in the diagnosis and prevention of HF, such as middle regional adrenomedullin (MR-proADM), highly sensitive cardiac troponin I/T( cTnI/TnT), soluble ST2 (sST2), growth differentiation factor (GDF)-15, Galectin-3, H-FABP(Heart type-Fatty Acid Binding Proteins), and Cystatin C (Cys-C). The gene discussed is TNNI3; the disease is hydrops fetalis.