In a randomized, double-blind controlled clinical trial involving people with obesity, blockade of IL-6 signaling through monthly infusions of tocilizumab (an IL-6 receptor antagonist) eliminated the aerobic exercise-induced reduction in epicardial and pericardial adipose tissue, as well as the expected increase in left ventricular mass (Christensen et al, 2019). The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.