In mice, FGF21 induces adipocyte production of adiponectin, which in turn acts as an indispensable downstream effector, conferring protective effects of FGF21 against obesity-induced metabolic complications and atherosclerosis (Holland et al, 2013; Lin et al, 2015; Lin et al, 2013). This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.