ADIPOQ and obesity due to melanocortin 4 receptor deficiency: In contrast, the adiponectin agonists mimic the effects of exercise on protection against several obesity-related complications, including alleviation of glucose intolerance and insulin resistance (Nicolas et al, 2020), reduction of liver steatosis and inflammation in mouse models of NAFLD (Xu et al, 2020), and preservation of cognitive functions and neural plasticity in diabetic mouse model (Lee et al, 2021).