ADIPOQ and obesity due to melanocortin 4 receptor deficiency: In animals, adiponectin deficiency exacerbates obesity-related insulin resistance and cardiometabolic syndrome, whereas replenishment with adiponectin or its receptor agonists (such as AdipoRon) has been shown to reverse these conditions (Kadowaki and Yamauchi, 2005; Xu et al, 2003; Yamauchi et al, 2001).