In mice, FGF21 induces adipocyte production of adiponectin, which in turn acts as an indispensable downstream effector, conferring protective effects of FGF21 against obesity-induced metabolic complications and atherosclerosis (Holland et al, 2013; Lin et al, 2015; Lin et al, 2013). The gene discussed is FGF21; the disease is obesity due to melanocortin 4 receptor deficiency.