Of note, the analysis of MYC transcriptional signatures was also performed on pan-cytokeratin (PANCK)-negative (nontumor) cells and showed a MYC fingerprint shutdown also in the tumor microenvironment (Extended Data Fig. 2b), demonstrating that the MYC-inhibitory effect of OMO-103 is both tumor cell autonomous and nonautonomous, reflecting the biological role of MYC in both compartments2. Here, MYC is linked to neoplasm.