At multivariable analysis, age, sex, transfer from acute care to CR after a hospitalization for HF, NYHA III/IV class, SBP < 100 mm Hg, moderate-to-severe anemia, eGFR < 30 mL/min/1.73 m2, sodium < 136 mEq/L, and NT-proBNP were identified as predictors of 1-year mortality (Model 1) (Table 2). The gene discussed is NPPB; the disease is anemia.