The covariates significantly associated with the primary outcome in model 2 (age, sex, SBP < 100 mm Hg, moderate-to-severe anemia, eGFR, sodium, NT-proBNP, and SFI) were used to build a point-based risk score, termed the SFI/NT-proBNP HF risk score (Fig. 2A). The gene discussed is NPPB; the disease is anemia (phenotype).