Consistent with the improved hepatic steatosis, the mRNA expression of genes related to lipid synthesis was decreased by steviol glycosides, where the expression of acetyl-CoA Carboxylase (accA) was decreased by both RebA and RebD and the sterol regulatory element binding protein 1 (srebp1c) by RebA only (Fig. 2F). The gene discussed is SREBF1; the disease is fatty liver disease.