Secondly, by analyzing PAQR3 from the perspective of epigenetics, we found that the methylation level of PAQR3 gene promoter was significantly changed in 10 types of tumors, and this epigenetic alteration led to the change of PAQR3 expression level in these tumors and could be used as a corresponding tumor marker42. Here, PAQR3 is linked to neoplasm.