The expression of CXCL10, MMP9, IL1B, CXCL8, and CXCR4 were co-regulated by IRF1, STAT1, STAT3, IKBKB, HDAC1, ETS1, and CEBPB, which were highly expressed in rosacea and acne lesions. The gene discussed is CXCR4; the disease is acne.