In acne lesions, all hub genes were negatively correlated with resting mast cells, whereas 9 (except CXCL10), 9 (except MMP9) and 8 (except MMP9 and CXCL10) hub genes were positively correlated with activated mast cells, gamma delta T cells, and neutrophils, respectively (Fig. 10B). This evidence concerns the gene MMP9 and acne.