In a model in which HaCaT cells treated with the antibacterial peptide LL-37 to simulate rosacea caused by Demodex folliculorum (D. folliculorum) infection, JAK 2 and STAT3 expression levels were increased, indicating that rosacea caused by D. folliculorum infection may be associated with the activation of the JAK/STAT signaling pathway71. This evidence concerns the gene STAT3 and rosacea.