Finally, IL1B, PTPRC, CXCL8, MMP9, CCL4, CXCL10, CD163, CCR5, CXCR4, and TLR8 were identified, and the corheatmap showed that there was a positive strong correlation between all hub genes in rosacea and acne lesions (Fig. 6C,D). The gene discussed is MMP9; the disease is acne.