In this study, we employed the LASSO-Cox regression algorithm to develop a prognostic signature comprising 11 autophagy-related genes (MAPK8IP1, CAMKK2, KIF5B, FADD, FKBP1B, EIF2AK3, DNAJB9, RGS19, TNFSF10, PEA15, and ARNT) for HCC. This evidence concerns the gene EIF2AK3 and hepatocellular carcinoma.