Hereby, combining the cancer genome atlas (TCGA) and gene expression omnibus (GEO) data, we carried out a pan-cancer exploration of PSMA7 at 20q concerning genetic alteration, survival state, gene expression, cellular pathway, molecular function, and potential drug screening, aiming to uncover the mechanisms of PSMA7 in tumorigenesis and clinical outcomes across diverse human cancers. Here, PSMA7 is linked to cancer.