A battery of metabolic tests measuring plasma levels of liver enzymes, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT), as well as total cholesterol (T-CHO) and triglyceride (TG) (Supplementary Fig. 17h–o), and an intraperitoneal glucose tolerance test (IPGTT) (Supplementary Fig. 18), consistently showed significant decreases in the AAVMUSE-ΔhFGF21-transduced NAFLD mice exposed to muscone as compared to the relevant control mice. The gene discussed is GPT; the disease is metabolic dysfunction-associated steatotic liver disease.