Genes associated with pentose phosphate (DERA, PGM2, NAMPT) and glycolysis (BPGM, LDHA, PFKFB3) revealed elevated expression in blood cells from active CAPS patients, and a decrease following anakinra treatment (Fig. 7D, Supplementary Fig. 7A). This evidence concerns the gene PFKFB3 and cryopyrin-associated periodic syndrome.