Interestingly, echoing the metabolic transition from oxidative metabolism to glycolysis seen post-LPS stimulation in macrophages28,29, we found that certain key glycolytic genes (such as PFKFB3 or BPGM) were upregulated in blood cells from CAPS patients collected during active disease, while others (ENO3) were downregulated. Here, PFKFB3 is linked to cryopyrin-associated periodic syndrome.