Consistent with this, unstimulated peripheral blood mononuclear cells (PBMCs) from CAPS patients showed a constitutive release of the pyroptotic marker galectin-3 and the cytokine IL-18 (Fig. 1B, C), with no detectable basal release of IL-1β or TNF-α (Fig. 1D,E). This evidence concerns the gene TNF and cryopyrin-associated periodic syndrome.