Subtyping FPLD without genetic testing is also challenging because the genotype-phenotype correlation differentiating the subtypes of FPLD is not clinically apparent; clinical features of distal lipoatrophy could be related to any of the monogenic forms of FPLD including LMNA, PPARG, PLIN1, CIDEC, LIPE, AKT2, and ADRA2A, or caused by polygenic influences (i.e. FPLD1) [4]. The gene discussed is ADRA2A; the disease is familial partial lipodystrophy.