Positron emission computed tomography (PET) studies using Dopamine 1 receptor (D1R) or Dopamine 2 receptor (D2R) radioligand have found patients with schizophrenia had a reduction in D1R and D2R availability in prefrontal cortex (PFC), especially in dorsolateral prefrontal cortex (DLPFC) [3–6]. The gene discussed is DRD1; the disease is schizophrenia.