CD274 and glioblastoma: In this work, we integrate antibodies and chemotherapeutic agents into a single micelle (angiopep2-aPD-L1@PTX nano-micelle, A2-APM) by crosslinking anti-PD-L1 antibodies (aPD-L1) and electrostatically binding paclitaxel (PTX) onto the amino groups of polyethylene glycol-poly-L-lysine (PEG-PLL) for effective GBM chemo-immunotherapy (Fig. 1a).