DNAJC5 and neuronal ceroid lipofuscinosis: Nevertheless, the precise relation between DNAJC5, its involvement in the secretion of misfolded proteins, and the disease is still unclear, as DNAJC5-deficient mice develop neurodegeneration whereas in vitro, adult-onset neuronal ceroid lipofuscinosis-associated DNAJC5 mutations inhibit the secretion of misfolded proteins.