The ABCA1 plays a key rolein transferring phosphatidylserine acrossthe cellular membrane to the outer leaflet,64 facilitating the external exposure of phosphatidylserine, whichis a prerequisite for EV release.64 Experimentalcerebral malaria studies have demonstrated a significant decreasein EVs in ABCA1 wild-type mice. The gene discussed is ABCA1; the disease is malaria.