Consequently, the increased levels of EVs observed inthe plasma of severe malaria patients could potentially influencethe integrity of the blood-brain barrier by transporting miR-451ato the endothelium.100 Malaria EVs alsoinclude plasmodial genomic DNA (gDNA).64,73 EVs facilitatethe transfer of plasmodial gDNA from parasites to human monocytes.Once inside the monocytes, this gDNA activates STING, an immune-relatedadapter present in the cytoplasm of innate immune cells, responsiblefor detecting microbial DNA. The gene discussed is STING1; the disease is malaria.