STAT3 and early-onset autosomal dominant Alzheimer disease: Additionally, studies by Zhao and Mehla showed that p-STAT3 deficiency could reduce inflammation, oxidative stress, and proliferation in liver damage, while inhibiting STAT3 could enhance cognitive function, functional connectivity, and cerebral blood flow in Alzheimer’s disease by reducing neuritic plaques, cerebral amyloid angiopathy, oxidative stress, and neuroinflammation [46, 47].