MITF and melanoma: Additionally, using published H3K27ac ChIP-Seq data, we identified this super-enhancer in the MITF-low metastatic melanoma cell lines (SKmel147, A375, and LOX IMVI) and found loss of H3K27ac in the MITF-high metastatic melanoma cell lines (501MEL, SKmel2, SKmel5, and SKmel239) (7, 8, 15) (Figure 5D).