INS and diabetes mellitus: Time-dependent Cox proportional hazard models were adjusted for sex, age, duration of diabetes, education level, current smoking, regular drinking, BMI, BP, HbA1c, serum cholesterol level, eGFR, and use of insulin (test for overall trend: LAP P=.001, VAI P<.001, and CVAI P=.006; test for nonlinear trend: LAP P=.048, VAI P=.002, and CVAI P=.51).