TNFRSF1A and periodontitis: Some immune related genes, such as the genetic modification of the Purinergic receptor P2X7 (P2X7R) [7], Tumor Necrosis Factor receptor-immunoglobulin Fc (TNFR: Fc) [8], Toll-like receptor 2 (TLR2) and Myomesin 2 (MYOM2) genes [9] are of great significance for the progression of periodontitis, and regulating the expression of related genes may be useful for the treatment of periodontitis.