As LGR5+ve CSCs share many of their characteristics with LGR5+ve CBC cells and most likely originate from these CBC cells during cancer initiation [22, 23], it is possible that a regenerative stem cell type similar to the CLU+ve RevSC is also present in the tumour tissue and may be either partly or entirely responsible for the repopulation of the CSC population following therapeutic treatment. Here, LGR5 is linked to cancer.