Additionally, treatment with TGFβ pushes mouse WT and tumour organoids towards a RevSC phenotype [49], while organoids co-cultured with mesenchymal cells pre-treated with TGFβ1 exhibit higher expression of RevSC genes, including Clu, compared to organoids co-cultured with vehicle pre-treated mesenchyme [108]. The gene discussed is CLU; the disease is neoplasm.