CLU and neoplasm: As LGR5+ve CSCs share many of their characteristics with LGR5+ve CBC cells and most likely originate from these CBC cells during cancer initiation [22, 23], it is possible that a regenerative stem cell type similar to the CLU+ve RevSC is also present in the tumour tissue and may be either partly or entirely responsible for the repopulation of the CSC population following therapeutic treatment.