In addition, Neu_c3_CST7, RSAD2_Neu, S100A2/Pabpc1_Neu, ISG15/Ifit3_Neu, CD74_Neu, PTGS2/Actg1_Neu, SPP1_Neu were high specific in all the four NSCLC-associated samples. The gene discussed is ISG15; the disease is non-small cell lung carcinoma.