Compared with atypical chronic myeloid leukemia and GATA2 deficiency, which are both from bone marrow, atypical chronic myeloid leukemia was also distributed with different proportion of Cd34_mNeu, Rps19_Neu, and Isg15_Neu, in addition to IL-7R + neurophils and Lgals1_mNeu (accounting for almost all the subgroup species of GATA2 defense). The gene discussed is RPS19; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.